Didymoteicho is a town located on the eastern edge of the Evros regional unit of East Macedonia and Thrace, in northeastern Greece. It is the seat of the municipality of the same name.
Forests dominate the banks and parts of the plain. Much of the area is used for farming. The main products are cattle, fruit and vegetables and some flowers. The hills dominate further west.
John V Palaiologos (1332–1391), a notable Byzantine Emperor was born is Didymoteicho.